Suppresses gastric acid secretion by blocking acid (proton) pump within gastric parietal cell.

Indications: Benign gastric, duodenal and NSAID induced ulcer, oesophageal reflux disease, ulcer associated with H. pylori infection, Zollinger- Ellison syndrome, gastric acid reduction during anaesthesia, acid- related dyspepsia and severe ulcerating reflux oesophagitis.

Cautions: To be used with caution in presence of liver diseases (dos e not more than 20 mg daily should be needed, reduced dose, not more than 8 mg daily in severe cases), gastric malignancy should be excluded before initiation of treatment.

Precautions: Avoid in pregnancy and breast-feeding.

Side Effects: Flatulence; abdominal pain, dyspepsia, nausea; vomiting, diarrhoea, dry mouth; constipation; Headache; dizziness. insomnia, drowsiness, malaisa, rash, pruritus, paraesthesia, vertigo, alopecia, gynaecomastia, impotence, stomatitis, encephalopathy in severe liver disease, hyponatraemia, reversible confusion, Agitation and hallucinations in the severely ill, visual impairment reported with high-dose injection.

Dose: By mouth, benign gastric and duodenal ulcers, 20 mg once daily for 4 weeks in duodenal ulceration or 8 weeks in gastric ulceration, in severe or recurrent cases increase to 40 mg daily, maintenance for recurrent duodenal ulcer, 20 mg once daily, prevention of relapse in duodenal ulcer, 10 mg daily increasing to 20 mg once daily if symptoms return.

NSAID- associated duodenal or gastric ulcer and gastroduodenal erosions, 20 mg once daily for 4 weeks, continued for further 4 weeks if not fully healed, prophylaxis in patients with a history of NSAID- associated duodenal or gastric ulcers, gastroduodenal lesions, or dyspeptic symptoms who require continued NSAID treatment, 200 mg once daily.

Duodenal or benign gastric ulcer associated with H. pylori, omeprazole 20 mg twice daily in combination with amoxicillin, 1000 mg twice daily or 500 mg 3 times daily and clarithromycin 500mg twice daily or metronidazole 400 mg twice daily or 400 mg 3 times daily, Zollinger- Ellison syndrome, initially 60 mg once daily, usual range 20-120 mg daily (above 80 mg in divided doses).

Gastric acid reduction during general anaesthesia 40 mg on the preceding evening then 40 mg 2-6 hours before surgery.

Gastro-oesophageal reflux disease, 20 mg once daily for 4 weeks, continued for further 4-8 weeks if not fully healed, 40 mg once daily has been given for 8 weeks in gastro- oesophageal reflux disease refractory to other treatment, maintenance, 20 mg once daily.

Acid reflux disease (long term management), 10 mg daily increasing to 20 mg once daily if symptoms return. Acid related dyspepsia, 10-20 mg once daily for 4- 8 weeks according to response.

Severe ulcerating reflux oesophagitis, child over 1 year, body weight 10-20 kg. 10 mg once daily increased if necessary to 20 mg once daily for 4-12 weeks, body weight over 20 kg, 20 mg once daily increased if necessary to 40 mg once daily for 4-12 weeks, to be initiated by hospital paediatrician.

By intravenous injection over 5 minutes or by intravenous infusion, prophylaxis of acid aspiration, 40 mg completed 1 hour before surgery.

Benign gastric ulcer, duodenal ulcer and gastro- oesophageal reflux, 40 mg once daily until oral administration possible.