Indications: for treating initial symptoms in patients at high risk of developing multiple sclerosis, and also for reducing the frequency of relapses in ambulatory patients with relapsing-remitting multiple sclerosis who have had at least 2 clinical relapses in the past 2 years.

Cautions: cardiac disorders

Renal impairment: no information available— manufacturer advises caution

Pregnancy: manufacturer advises avoid—no information available

Breast-feeding: manufacturer advises caution—no information available

Side Effects: hypersensitivity reactions; flushing, chest pain, palpitation, tachycardia, and dyspnea may occur within minutes of injection; nausea, constipation, dyspepsia; syncope, anxiety, asthenia, depression, headache, tremor, sweating; oedema, lymphadenopathy; hypertonia, back pain, arthralgia, influenza-like symptoms; injection-site reactions, rash; rarely seizures.

Dose: By subcutaneous injection, ADULT over 18 years, 20 mg daily.